BACKGROUND & OBJECTIVE:Osmotic pumps Caregiver feeding practices for infants and toddlers and their eating behaviors in Singapore are promising methods for controlled drug release.They are devices used for delivering drugs orally or through implantation.The primary aim of this research is to develop a Norfloxacin oral push-pull osmotic pump capable of providing a controlled drug release while ensuring that the release remains unaffected by the hydrodynamics and pH of the surrounding medium.METHODOLOGY:The core tablet was fabricated using direct compression and subsequently coated with HPMC, PEG-400, sorbitol, and acetone as a solvent.Swelling polymers, specifically Guar Gum (Cyamopsis tetragonoloba), Xanthan Gum (polysaccharide B-1459), and Hydroxypropyl Methylcellulose were also included in the fabrication of the core tablet, with NaCl serving as the cosmogenic.
RESULTS:The formulations exhibited favorable flow properties.Friability, hardness, and weight variation testing yielded values within limits, indicating satisfactory outcomes.The drug content uniformity ranged from 98.00% to 99.67%, indicating uniform drug distribution within the formulations.
Thermal analysis suggested that the sample was thermally stable.Dissolution studies revealed an in vitro dissolution rate of 98.5% over 15 hours.Release kinetics analysis using four models indicated controlled drug release, with the value of regression (R2) confirming this observation and the n exponent suggesting non-Fickian diffusion.CONCLUSION:Osmotic pumps offer zero-order drug delivery, ensuring Risk Factor Profile of Motorcycle Crash Victims in Rural Kenya steady-state drug release to maintain therapeutic levels for a more extended period; thus, they minimize side effects and improve patient compliance.